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  1. NIF
  2. NIF-11899

Representation of chromosomal boundary regions

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    • NIF

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      This landmark paper describes the identification of chromosomal boundary regions. http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC3356448/

      references other papers describing other types of chromosomal boundaries:

      A and B compartments http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2858594/

      Lamina-Associated Domains (LADs)
      http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pubmed/18463634
      http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pubmed/20513434

      replication time zones
      http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2813472/
      http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2877573/

      Large Organized Chromatin K9-modification (LOCK) domains
      http://www-ncbi-nlm-nih-gov.liboff.ohsu.edu/pmc/articles/PMC2632725/

      The GENO/SO should have a representation of these different types of chromosomal boundaries, and we should further identify data sources to ingest to support chromosomal level correlations of genotype to phenotype and display on the genome browser.

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            brushm Matthew Brush
            mhaendel Melissa Haendel
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