Details
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Bug
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Resolution: Duplicate
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Major
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None
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None
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None
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NIF
Description
We need a section of GENO that records the properties of an "allele" on phenotype/gene expression. These "alleles" could be genetic changes or externally applied changes (like morpholinos/RNAi, transient transfection).
The kinds of things that need to be included here are:
1. up/down (over/under) expression For example, as resulting from Transgenic/Actin promoter (up expression) or RNAi (down expression)
2. hypermorph (genetic changes that result in increased phenotype).
3. hypomorph (genetic changes that result in decreased phenotype).
4. environmentally-dependent (resulting from drugs, temperature, etc.). changes in phenotype are only observed when an allele is exposed to a particular environment.
4b. temperature-specific. different phenotypes are observed when this allele is exposed to a different temperature.
An allele can have >1 of the above properties. For example, I believe that a single allele might be hypomorphic at one temp, and hypermorphic at another.
There may need to be specific subtypes for each of these, but i think these are the general layout of the classes.
Attachments
Issue Links
- is related to
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NIF-11702 Curate disease attributes - genecity, somatic/germline, trait/disease
- Closed