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  1. NIF
  2. NIF-11599

Add allele properties

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    • NIF

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      We need a section of GENO that records the properties of an "allele" on phenotype/gene expression. These "alleles" could be genetic changes or externally applied changes (like morpholinos/RNAi, transient transfection).

      The kinds of things that need to be included here are:
      1. up/down (over/under) expression For example, as resulting from Transgenic/Actin promoter (up expression) or RNAi (down expression)
      2. hypermorph (genetic changes that result in increased phenotype).
      3. hypomorph (genetic changes that result in decreased phenotype).
      4. environmentally-dependent (resulting from drugs, temperature, etc.). changes in phenotype are only observed when an allele is exposed to a particular environment.
      4b. temperature-specific. different phenotypes are observed when this allele is exposed to a different temperature.

      An allele can have >1 of the above properties. For example, I believe that a single allele might be hypomorphic at one temp, and hypermorphic at another.
      There may need to be specific subtypes for each of these, but i think these are the general layout of the classes.

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              brushm Matthew Brush
              nlw Nicole Washington
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